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Original scientific paper

Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3-Diphenyl-1,3-propanedione

By
Emir Horozić ,
Emir Horozić
Contact Emir Horozić

Faculty of Technology, University of Tuzla , Tuzla , Bosnia and Herzegovina

Jasmin Suljagić ,
Jasmin Suljagić

Faculty of Technology, University of Tuzla , Tuzla , Bosnia and Herzegovina

Darja Husejnagić ,
Darja Husejnagić

Faculty of Natural Sciences, University of Tuzla , Tuzla , Bosnia and Herzegovina

Nusreta Hasić ,
Nusreta Hasić

Faculty of Natural Sciences, University of Tuzla , Tuzla , Bosnia and Herzegovina

Amra Bratovčić
Amra Bratovčić

Faculty of Technology, University of Tuzla , Tuzla , Bosnia and Herzegovina

Abstract

Schiff bases are organic compounds formed by the reaction of the primary amine with carbonyl compounds (aldehydes or ketones). These are mainly bi- or tridentate ligands capable of forming very stable complexes with transitional metals. They are used as catalysts in oxygenation, hydrolysis, electro-reduction and decomposition reactions. Many Shiff bases show significant anti-tumor and antimicrobial activity, which is why they are the subject of research by many scientists in the world. In this paper Schiff's base from benzidine and 1,3-diphenyl-1,3-propanedione was synthesized. To characterize the product, FTIR spectroscopy and stereo-microscopy were used. In order to determine biological activity, antibacterial, antifungal and antioxidant activity of the product was tested. The results showed that the interaction of benzidine and 1,3-diphenylpropandione results in a Schiff base showing antibacterial, antifungal and antioxidant activity.

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Authors retain copyright. This work is made freely available online under an open-access model under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-http://creativecommons.org/licenses/by-nc-nd/4.0/BY-NC-ND 4.0).

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