×
Home Current Archive Editorial board
News Contact
Original scientific paper

Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3-Diphenyl-1,3-propanedione

By
Emir Horozić ,
Emir Horozić
Contact Emir Horozić

Faculty of Technology, University of Tuzla, Tuzla, Bosnia and Herzegovina

Jasmin Suljagić ,
Jasmin Suljagić

Faculty of Technology, University of Tuzla, Tuzla, Bosnia and Herzegovina

Darja Husejnagić ,
Darja Husejnagić

Faculty of Natural Sciences, University of Tuzla, Tuzla, Bosnia and Herzegovina

Nusreta Hasić ,
Nusreta Hasić

Faculty of Natural Sciences, University of Tuzla, Tuzla, Bosnia and Herzegovina

Amra Bratovčić
Amra Bratovčić

Faculty of Technology, University of Tuzla, Tuzla, Bosnia and Herzegovina

Abstract

Schiff bases are organic compounds formed by the reaction of the primary amine with carbonyl compounds (aldehydes or ketones). These are mainly bi- or tridentate ligands capable of forming very stable complexes with transitional metals. They are used as catalysts in oxygenation, hydrolysis, electro-reduction and decomposition reactions. Many Shiff bases show significant anti-tumor and antimicrobial activity, which is why they are the subject of research by many scientists in the world. In this paper Schiff's base from benzidine and 1,3-diphenyl-1,3-propanedione was synthesized. To characterize the product, FTIR spectroscopy and stereo-microscopy were used. In order to determine biological activity, antibacterial, antifungal and antioxidant activity of the product was tested. The results showed that the interaction of benzidine and 1,3-diphenylpropandione results in a Schiff base showing antibacterial, antifungal and antioxidant activity.

Citation

Authors retain copyright. This work is made freely available online under an open-access model under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-http://creativecommons.org/licenses/by-nc-nd/4.0/BY-NC-ND 4.0).

Article metrics

Google scholar: See link

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.