Department of Chemistry, Biochemistry and Enviromental Protection, Faculty of Science, University of Novi Sad, Novi Sad, Serbia
Department of Chemistry, Biochemistry and Enviromental Protection, Faculty of Science, University of Novi Sad, Novi Sad, Serbia
Department of Chemistry, Biochemistry and Enviromental Protection, Faculty of Science, University of Novi Sad, Novi Sad, Serbia
Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
Retention behavior of some N-(4-phenylsubstituted)-2,3-diphenylpropanamides was investigated on reversed phase thin layer chromatography (RP-C18). Retention constants of investigated compounds were determined in the following solvent systems: water-ethanol, watern-propanol and water-i-propanol. Linear relationships were obtained between retention, RM and volume fraction of organic solvent, ϕ. As a measure of lipophilicity of tested propanamides, Hansch`s lipophilicity parameter, π, were calculated. Chromatography retention constants RM0 were correlated with Hansch`s lipophilicity parameter, and good linear relationships were obtained. These results confirm, that retention constants, (RM0 ), determined in reversed phase thin-layer chromatography (RP-TCL) can be used, as criteria of lipophilicity.
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