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Original scientific paper

Computational study of amiloride – a WADA banned molecule

By
Svetlana Pelemiš ,
Svetlana Pelemiš

Faculty of Technology Zvornik, University of East Sarajevo, Lukavica, Bosnia and Herzegovina

Sanja J. Armaković ,
Sanja J. Armaković

Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia

Association for the International Development of Academic and Scientific Collaboration, Novi Sad, Serbia

Bogdan T. Tomić ,
Bogdan T. Tomić

Faculty of Sport and Tourism – TIMS, Educons University, Sremska Mitrovica, Serbia

Stevan Armaković
Stevan Armaković
Contact Stevan Armaković

Department of Physics, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia

Association for the International Development of Academic and Scientific Collaboration, Novi Sad, Serbia

Abstract

Amiloride (AMI) is a representative of diuretics. Among other purposes, it is utilized for high blood pressure or swelling induced by heart failure. While it is identified as one of the safest medicines available, it is also listed in the World Anti-doping Agency’s list of substances banned in sport, because it is considered a masking agent. Since it has been abused in sports, methods have been developed to be able to detect it during doping controls. We have computationally investigated selected structural and reactive properties of the AMI molecule in this work, employing density functional theory calculations.

Citation

Authors retain copyright. This work is made freely available online under an open-access model under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-http://creativecommons.org/licenses/by-nc-nd/4.0/BY-NC-ND 4.0).

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