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Original scientific paper

SYNTHESIS 4-NITRO-41'-BIPHENYL BY CROSS-COUPLING REACTION

By
Ljubica Vasiljević ,
Ljubica Vasiljević

Faculty of Technology, University of East Sarajevo , Lukavica , Bosnia and Herzegovina

Ivan Ćirić ,
Ivan Ćirić

Higher Eduacation School for Applied Studies of Technology, , Šabac , Serbia

Dragana Grujić
Dragana Grujić

Faculty of Technology, University of Banja Luka , Banja Luka , Bosnia and Herzegovina

Abstract

Biphenylsarean important class of organic compounds. Theyare importantin the field of natural products, polymersand the contemporary medical materials. Synthetic route cross-coupling (Suzukis) reaction, starting from benzenevia the iodoniumsaltto 4-nitro-4'-metilbiphenyl is chosen in this study. The resulting intermediates and final product of the synthesis was confirmed by determination of the melting point and infrared spectroscopy. The final product was confirmed by NMR spectroscopy. This synthetic pathway to obtain biphenyls, which may be a key intermediate in many syntheses, there area number of advantages over the previously-defined synthetic routes due to the tolerance in respect of a wide range of functional groups, regio and stereoselectivity and specificity. In addition, theinorganic productsin the synthesis of non-toxic so farbeen used as heavy metals (Hg (II), Tl(III), Pb(IV)) and can be easily separated. High yields of the reaction products are obtained.

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Authors retain copyright. This work is made freely available online under an open-access model under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-http://creativecommons.org/licenses/by-nc-nd/4.0/BY-NC-ND 4.0).

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