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Original scientific paper
Published: 01.12.2019.
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https://doi.org/10.7251/jepm1902112h

Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3‐Diphenyl‐1,3‐propanedione

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Emir Horozić ,
Emir Horozić
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Jasmin Suljagić ,
Jasmin Suljagić
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Darja Husejnagić ,
Darja Husejnagić
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Nusreta Hasić ,
Nusreta Hasić
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Amra Bratovčić
Amra Bratovčić
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Abstract

Schiff bases are organic compounds formed by the reaction of the primary aminewith carbonyl compounds (aldehydes or ketones). These are mainly bi- or tridentateligands capable of forming very stable complexes with transitional metals. They areused as catalysts in oxygenation, hydrolysis, electro-reduction and decompositionreactions. Many Shiff bases show significant anti-tumor, antimicrobial and antifungalactivity, which are the subject of research by many scientists in the world.In this paper Schiff base from benzidine and 1,3-diphenyl-1,3-propanedione wassynthesized. To characterize the product, FTIR spectroscopy and stereo-microscopywere used. In order to determine biological activity, antibacterial, antifungal andantioxidant activity of the product was tested.The results showed that the interaction of benzidine and 1,3-diphenylpropanedioneresults in a Schiff base showing antibacterial, antifungal and antioxidant activity.

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Authors retain copyright. This work is made freely available online under an open-access model under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC-http://creativecommons.org/licenses/by-nc-nd/4.0/BY-NC-ND 4.0).

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