The aim of this paper was to develop and optimize the carvedilol tablets formulation using the full factorial design. The content of binder (PVP K30), content of disintegrant (crospovidone) and main compression force were used as the independent variables. Tablets were prepared by wet granulation. The percentage of released carvedilol from prepared...

By Predrag Sibinovic, Valentina Marinkovic, Radoslav Palic, Ivan Savic, Ivana Savic -Gajic, Dragan Milenovic, Rada Jankovic