Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3-Diphenyl-1,3-propanedione

  • Emir Horozić Faculty of Technology, University of Tuzla, Univerzitetska 8, 75000 Tuzla, Bosnia and Herzegovina
  • Jasmin Suljagić Faculty of Technology, University of Tuzla, Univerzitetska 8, 75000 Tuzla, Bosnia and Herzegovina
  • Darja Husejnagić Faculty of Natural Sciences, University of Tuzla, Univerzitetska 4, 75000 Tuzla, Bosnia and Herzegovina
  • Nusreta Hasić Faculty of Natural Sciences, University of Tuzla, Univerzitetska 4, 75000 Tuzla, Bosnia and Herzegovina
  • Amra Bratovčić Faculty of Technology, University of Tuzla, Univerzitetska 8, 75000 Tuzla, Bosnia and Herzegovina

Abstract

Schiff bases are organic compounds formed by the reaction of the primary amine with carbonyl compounds (aldehydes or ketones). These are mainly bi- or tridentate ligands capable of forming very stable complexes with transitional metals. They are used as catalysts in oxygenation, hydrolysis, electro-reduction and decomposition reactions. Many Shiff bases show significant anti-tumor and antimicrobial activity, which is why they are the subject of research by many scientists in the world. In this paper Schiff's base from benzidine and 1,3-diphenyl-1,3-propanedione was synthesized. To characterize the product, FTIR spectroscopy and stereo-microscopy were used. In order to determine biological activity, antibacterial, antifungal and antioxidant activity of the product was tested. The results showed that the interaction of benzidine and 1,3-diphenylpropandione results in a Schiff base showing antibacterial, antifungal and antioxidant activity.


Keywords: Schiff base, benzidine, FTIR, UV/Vis, antimicrobial activity.

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Published
2020-03-12
How to Cite
HOROZIĆ, Emir et al. Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3-Diphenyl-1,3-propanedione. Journal of Engineering & Processing Management, [S.l.], v. 11, n. 2, p. 112-116, mar. 2020. ISSN 2566-3615. Available at: <https://jepm.tfzv.ues.rs.ba/index.php/Journal/article/view/203>. Date accessed: 29 nov. 2020. doi: https://doi.org/10.7251/JEPM1902112H.