Original scientific paper

CHROMATOGRAPHIC BEHAVIOR AND LIPOPHILICITY OF N-(4-PHENYLSUBSTITUTED)-2,3-DIPHENYLPROPANAMIDES

Authors

• • Dj. Vaštag
  • University of Novi Sad, Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Enviromental Protection, Serbia
• • N. Perišić-Janjić
  • University of Novi Sad, Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Enviromental Protection, Serbia
• • S. Apostolov
  • University of Novi Sad, Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Enviromental Protection, Serbia
• • S. Petrovic
  • University of Belgrade, Faculty of Technology and Metallurgy, Serbia

Abstract

Retention behavior of some N-(4-phenylsubstituted)-2,3-diphenylpropanamides was investigated on reversed phase thin layer chromatography (RP-C18). Retention constants of investigated compounds were determined in the following solvent systems: water-ethanol, watern-propanol and water-i-propanol. Linear relationships were obtained between retention, RM and volume fraction of organic solvent, ϕ. As a measure of lipophilicity of tested propanamides, Hansch`s lipophilicity parameter, π were calculated. Chromatography retention constants RM0 were correlated with Hansch`s lipophilicity parameter, and good linear relationships were obtained. These results confirm, that retention constants, (RM0 ), determined in reversed phase thin-layer chromatography (RP-TCL) can be used, as criteria of lipophilicity.

Keywords: Chromatography, Compound, Structure

How to Cite: Vaštag, D. , Perišić-Janjić, N. , Apostolov, S. & Petrovic, S. (2011) “CHROMATOGRAPHIC BEHAVIOR AND LIPOPHILICITY OF N-(4-PHENYLSUBSTITUTED)-2,3-DIPHENYLPROPANAMIDES”, Journal of Engineering & Processing Management. 3(1).