Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3-Diphenyl-1,3-propanedione

Emir Horozić; Jasmin Suljagić; Darja Husejnagić; Nusreta Hasić; Amra Bratovčić

doi:10.7251/jepm1902112h

Original scientific paper

Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3-Diphenyl-1,3-propanedione

Authors

- Emir Horozić
- University of Tuzla, Faculty of Technology, Tuzla, Tuzla, Bosnia and Herzegovina
- Jasmin Suljagić
- University of Tuzla, Faculty of Technology, Tuzla, Tuzla, Bosnia and Herzegovina
- Darja Husejnagić
- University of Tuzla, Faculty of Technology, Tuzla, Tuzla, Bosnia and Herzegovina
- Nusreta Hasić
- University of Tuzla, Faculty of Technology, Tuzla, Tuzla, Bosnia and Herzegovina
- Amra Bratovčić
- University of Tuzla, Faculty of Technology, Tuzla, Tuzla, Bosnia and Herzegovina

Abstract

Schiff bases are organic compounds formed by the reaction of the primary amine with carbonyl compounds (aldehydes or ketones). These are mainly bi- or tridentate ligands capable of forming very stable complexes with transitional metals. They are used as catalysts in oxygenation, hydrolysis, electro-reduction and decomposition reactions. Many Shiff bases show significant anti-tumor and antimicrobial activity, which is why they are the subject of research by many scientists in the world. In this paper Schiff's base from benzidine and 1,3-diphenyl-1,3-propanedione was synthesized. To characterize the product, FTIR spectroscopy and stereo-microscopy were used. In order to determine biological activity, antibacterial, antifungal and antioxidant activity of the product was tested. The results showed that the interaction of benzidine and 1,3-diphenylpropandione results in a Schiff base showing antibacterial, antifungal and antioxidant activity.

Keywords: Schiff base, benzidine, FTIR, UV/Vis, antimicrobial activity

How to Cite: Horozić, E. , Suljagić, J. , Husejnagić, D. , Hasić, N. & Bratovčić, A. (2019) “Synthesis, characterization and in vitro biological evaluation of the Schiff base derived from Benzidine and 1,3-Diphenyl-1,3-propanedione”, Journal of Engineering & Processing Management. 11(2). doi: https://doi.org/10.7251/jepm1902112h